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List of publications
Patents/ Research tools
1. US Patent 10,459,212, Optical trap for rheological characterization of biological materials, July 2019, K Tanner, B Blehm, A Devine
2. NIH EIR #06981- Humanizing the Innate Immune System of the Zebrafish for Personalized Immunotherapy- June 2017, K Tanner, A Devine
3. International patent application No. PCT/US2016/044850 filed July 2016, NIH #E-251-2015, An In-Situ Calibrated Optical Trap for Rheological Characterization of Complex Materials, K Tanner, B Blehm, A Devine
4. U.S. Patent Application No. 62/198,554; filed July 2015, NIH #E-251-2015, An In-Situ Calibrated Optical Trap for Rheological Characterization of Complex Materials, K Tanner, B Blehm, A Devine
Peer-Reviewed Articles
Since joining the NIH:
1. Foss, A., Zanoni, M., So, W. Y., Jenkins, L., Tosatto, L., Bartolini, D., . . . Tanner, K*. (2020). Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway, Under revision Soft Matter
2. Jackson, S., Meeks, C., Vézina, A., Robey, R., Tanner, K., & Gottesman, M. (2019). Model systems for studying the blood-brain barrier: Applications and challenges. Biomaterials, 214, 119217. doi: 10.1016/j.biomaterials.2019.05.028
3. Paul, C., Bishop, K., Devine, A., Paine, E., Staunton, J., & Thomas, S., Jenkins, L., Morgan, N., Sood, R., Tanner, K. (2019). Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish. Cell Systems, 9(2), 187-206.e16. doi: 10.1016/j.cels.2019.0
Selected for cover August 2019 issue, Cell Systems
4. Staunton, J., So, W., Paul, C., & Tanner, K. (2019). High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics. Proceedings Of The National Academy Of Sciences, 116(29), 14448-14455. doi: 10.1073/pnas.1814271116
5. Paul, C., Hruska, A., Staunton, J., Burr, H., Daly, K., & Kim, J., Tanner, K. (2019). Probing cellular response to topography in three dimensions. Biomaterials, 197, 101-118. doi: 10.1016/j.biomaterials.2019.01.009
6. Paul, C., Devine, A., Bishop, K., Xu, Q., Wulftange, W., & Burr, H. Daly KM, Lewis C, Green DS, Staunton JR, Choksi S, Liu ZG, Sood R, Tanner K. (2019). Human macrophages survive and adopt activated genotypes in living zebrafish. Scientific Reports, 9(1). doi: 10.1038/s41598-018-38186-y
7. Tanner, K. (2018). Perspective: The role of mechanobiology in the etiology of brain metastasis. APL Bioengineering, 2(3), 031801. doi: 10.1063/1.5024394
8. Ricca, B., Venugopalan, G., Furuta, S., Tanner, K., Orellana, W., & Reber, C. Brownfield DG, Bissell MJ, Fletcher DA. (2018). Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. Elife, 7. doi: 10.7554/elife.26161
9. Staunton, J., Blehm, B., Devine, A., & Tanner, K. (2017). In situ calibration of position detection in an optical trap for active microrheology in viscous materials. Optics Express, 25(3), 1746. doi: 10.1364/oe.25.001746
10. Staunton, J., Vieira, W., Fung, K., Lake, R., Devine, A., & Tanner, K. (2016). Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ-Calibrated Optical Trap-Based Active Microrheology. Cellular And Molecular Bioengineering, 9(3), 398-417. doi: 10.1007/s12195-016-0460-9
11. Kim, J., & Tanner, K. (2016). Three-Dimensional Patterning of the ECM Microenvironment Using Magnetic Nanoparticle Self Assembly. Curr Protoc Cell Biol., 3 1;70:25.3.1-25.3.14. doi: 10.1002/0471143030.cb2503s70.
12. Afasizheva, A., Devine, A., Tillman, H., Fung, K., Vieira, W., & Blehm, B. Kotobuki Y, Busby B, Chen EI, Tanner K. (2016). Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival. BMC Cancer, 16(1). doi: 10.1186/s12885-016-2211-7
13. Blehm, B., Devine, A., Staunton, J., & Tanner, K. (2016). In vivo tissue has non-linear rheological behavior distinct from 3D biomimetic hydrogels, as determined by AMOTIV microscopy. Biomaterials, 83, 66-78. doi: 10.1016/j.biomaterials.2015.12.019
14. Kim, J., & Tanner, K. (2015). Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models. Frontiers In Oncology, 5. doi: 10.3389/fonc.2015.00170
15. Kim, J., Staunton, J., & Tanner, K. (2015). Independent Control of Topography for 3D Patterning of the ECM Microenvironment. Advanced Materials, 28(1), 132-137. doi: 10.1002/adma.201503950
16. Blehm, B., Jiang, N., Kotobuki, Y., & Tanner, K. (2015). Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma. Biomaterials, 56, 129-139. doi: 10.1016/j.biomaterials.2015.03.041
17. Tanner, K., & Gottesman, M. (2015). Beyond 3D culture models of cancer. Science Translational Medicine, 7(283), 283ps9-283ps9. doi: 10.1126/scitranslmed.3009367
18. Brownfield, D., Venugopalan, G., Lo, A., Mori, H., Tanner, K., Fletcher, D., & Bissell, M. (2013). Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules. Current Biology, 23(8), 703-709. doi: 10.1016/j.cub.2013.03.032
19. Boudreau, A., Tanner, K., Wang, D., Geyer, F., Reis-Filho, J., & Bissell, M. (2013). 14-3-3σ stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion. Proceedings Of The National Academy Of Sciences, 110(41), E3937-E3944. doi: 10.1073/pnas.1315022110
20. Tanner, K. (2012). Regulation of the basement membrane by epithelia generated forces. Physical Biology, 9(6), 065003. doi: 10.1088/1478-3975/9/6/065003
Before the NIH:
21. Tanner, K., Mori, H., Mroue, R., Bruni-Cardoso, A., & Bissell, M. (2012). Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proceedings Of The National Academy Of Sciences, 109(6), 1973-1978. doi: 10.1073/pnas.1119578109
22. Tanner, K., Boudreau, A., Bissell, M., & Kumar, S. (2010). Dissecting Regional Variations in Stress Fiber Mechanics in Living Cells with Laser Nanosurgery. Biophysical Journal, 99(9), 2775-2783. doi: 10.1016/j.bpj.2010.08.071
23. Ulrich, T., Jain, A., Tanner, K., MacKay, J., & Kumar, S. (2010). Probing cellular mechanobiology in three-dimensional culture with collagen agarose matrices. Biomaterials, 31(7), 1875-1884. doi: 10.1016/j.biomaterials.2009.10.047
24. Tanner, K., Ferris, D., Lanzano, L., Mandefro, B., Mantulin, W., & Gardiner, D. et al. (2009). Coherent Movement of Cell Layers during Wound Healing by Image Correlation Spectroscopy. Biophysical Journal, 97(7), 2098-2106. doi: 10.1016/j.bpj.2009.06.052
25. Tanner, K., Beitel, E., D’Amico, E., Mantulin, W., & Gratton, E. (2006). Effects of vasodilation on intrinsic optical signals in the mammalian brain: a phantom study. Journal Of Biomedical Optics, 11(6), 064020. doi: 10.1117/1.2398920
26. Tanner, K., D’Amico, E., Kaczmarowski, A., Kukreti, S., Malpeli, J., Mantulin, W., & Gratton, E. (2005). Spectrally resolved neurophotonics: a case report of hemodynamics and vascular components in the mammalian brain. Journal Of Biomedical Optics, 10(6), 064009. doi: 10.1117/1.2137291
Non-peer reviewed preprints:
1. Foss, A., Zanoni, M., So, W. Y., Jenkins, L., Tosatto, L., Bartolini, D., . . . Tanner, K*. (2020). Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway. bioRxiv 207233, doi:10.1101/2020.07.16.207233
2. Kong, M., Updegrove, T., B., Constantino, M., A., Gallardo, D., L., Wu,I., Fitzgerald, D., J.*, Tanner, K.*, Ramamurthi, K.* (2020). Cell-specific cargo delivery using synthetic bacterial spores. bioRxiv 94760, doi.org/10.1101/2020.02.13.94760
3. Paul, C., Hruska, A., Staunton J.R., Burr, H., A., Jiang, N., Kim, J., Tanner, K. (2017). Decoupling cellular response to topography and stiffness in three dimensions. bioRxiv 232066; doi: https://doi.org/10.1101/232066
4. Paul, C., Bishop, K., Devine, A., Wulftange, W., Paine, E., Staunton J.R., Shema, S., Bliskovsky, V., Jenkins, L., Morgan, N., Sood, R., Tanner, K. (2017). Tissue architectural cues drive the emergence of non-random trafficking of human tumor cells in the larval zebrafish. bioRxiv 233361; doi: https://doi.org/10.1101/233361
5. Paul, C., Devine, A., Bishop, K., Xu, Q., Daly, K.M., Lewis, C., Green, D.S., Staunton J.R., Liu, Z., Sood, R., Tanner, K. (2017). Human macrophages survive and adopt activated genotypes in living zebrafish. bioRxiv 181685; doi: https://doi.org/10.1101/181685
Selected for preLight, https://prelights.biologists.com/highlights/human-macrophages-survive-adopt-activated-genotypes-living-zebrafish/
1. US Patent 10,459,212, Optical trap for rheological characterization of biological materials, July 2019, K Tanner, B Blehm, A Devine
2. NIH EIR #06981- Humanizing the Innate Immune System of the Zebrafish for Personalized Immunotherapy- June 2017, K Tanner, A Devine
3. International patent application No. PCT/US2016/044850 filed July 2016, NIH #E-251-2015, An In-Situ Calibrated Optical Trap for Rheological Characterization of Complex Materials, K Tanner, B Blehm, A Devine
4. U.S. Patent Application No. 62/198,554; filed July 2015, NIH #E-251-2015, An In-Situ Calibrated Optical Trap for Rheological Characterization of Complex Materials, K Tanner, B Blehm, A Devine
Peer-Reviewed Articles
Since joining the NIH:
1. Foss, A., Zanoni, M., So, W. Y., Jenkins, L., Tosatto, L., Bartolini, D., . . . Tanner, K*. (2020). Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway, Under revision Soft Matter
2. Jackson, S., Meeks, C., Vézina, A., Robey, R., Tanner, K., & Gottesman, M. (2019). Model systems for studying the blood-brain barrier: Applications and challenges. Biomaterials, 214, 119217. doi: 10.1016/j.biomaterials.2019.05.028
3. Paul, C., Bishop, K., Devine, A., Paine, E., Staunton, J., & Thomas, S., Jenkins, L., Morgan, N., Sood, R., Tanner, K. (2019). Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish. Cell Systems, 9(2), 187-206.e16. doi: 10.1016/j.cels.2019.0
Selected for cover August 2019 issue, Cell Systems
4. Staunton, J., So, W., Paul, C., & Tanner, K. (2019). High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics. Proceedings Of The National Academy Of Sciences, 116(29), 14448-14455. doi: 10.1073/pnas.1814271116
5. Paul, C., Hruska, A., Staunton, J., Burr, H., Daly, K., & Kim, J., Tanner, K. (2019). Probing cellular response to topography in three dimensions. Biomaterials, 197, 101-118. doi: 10.1016/j.biomaterials.2019.01.009
6. Paul, C., Devine, A., Bishop, K., Xu, Q., Wulftange, W., & Burr, H. Daly KM, Lewis C, Green DS, Staunton JR, Choksi S, Liu ZG, Sood R, Tanner K. (2019). Human macrophages survive and adopt activated genotypes in living zebrafish. Scientific Reports, 9(1). doi: 10.1038/s41598-018-38186-y
7. Tanner, K. (2018). Perspective: The role of mechanobiology in the etiology of brain metastasis. APL Bioengineering, 2(3), 031801. doi: 10.1063/1.5024394
8. Ricca, B., Venugopalan, G., Furuta, S., Tanner, K., Orellana, W., & Reber, C. Brownfield DG, Bissell MJ, Fletcher DA. (2018). Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. Elife, 7. doi: 10.7554/elife.26161
9. Staunton, J., Blehm, B., Devine, A., & Tanner, K. (2017). In situ calibration of position detection in an optical trap for active microrheology in viscous materials. Optics Express, 25(3), 1746. doi: 10.1364/oe.25.001746
10. Staunton, J., Vieira, W., Fung, K., Lake, R., Devine, A., & Tanner, K. (2016). Mechanical Properties of the Tumor Stromal Microenvironment Probed In Vitro and Ex Vivo by In Situ-Calibrated Optical Trap-Based Active Microrheology. Cellular And Molecular Bioengineering, 9(3), 398-417. doi: 10.1007/s12195-016-0460-9
11. Kim, J., & Tanner, K. (2016). Three-Dimensional Patterning of the ECM Microenvironment Using Magnetic Nanoparticle Self Assembly. Curr Protoc Cell Biol., 3 1;70:25.3.1-25.3.14. doi: 10.1002/0471143030.cb2503s70.
12. Afasizheva, A., Devine, A., Tillman, H., Fung, K., Vieira, W., & Blehm, B. Kotobuki Y, Busby B, Chen EI, Tanner K. (2016). Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival. BMC Cancer, 16(1). doi: 10.1186/s12885-016-2211-7
13. Blehm, B., Devine, A., Staunton, J., & Tanner, K. (2016). In vivo tissue has non-linear rheological behavior distinct from 3D biomimetic hydrogels, as determined by AMOTIV microscopy. Biomaterials, 83, 66-78. doi: 10.1016/j.biomaterials.2015.12.019
14. Kim, J., & Tanner, K. (2015). Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models. Frontiers In Oncology, 5. doi: 10.3389/fonc.2015.00170
15. Kim, J., Staunton, J., & Tanner, K. (2015). Independent Control of Topography for 3D Patterning of the ECM Microenvironment. Advanced Materials, 28(1), 132-137. doi: 10.1002/adma.201503950
16. Blehm, B., Jiang, N., Kotobuki, Y., & Tanner, K. (2015). Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma. Biomaterials, 56, 129-139. doi: 10.1016/j.biomaterials.2015.03.041
17. Tanner, K., & Gottesman, M. (2015). Beyond 3D culture models of cancer. Science Translational Medicine, 7(283), 283ps9-283ps9. doi: 10.1126/scitranslmed.3009367
18. Brownfield, D., Venugopalan, G., Lo, A., Mori, H., Tanner, K., Fletcher, D., & Bissell, M. (2013). Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules. Current Biology, 23(8), 703-709. doi: 10.1016/j.cub.2013.03.032
19. Boudreau, A., Tanner, K., Wang, D., Geyer, F., Reis-Filho, J., & Bissell, M. (2013). 14-3-3σ stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion. Proceedings Of The National Academy Of Sciences, 110(41), E3937-E3944. doi: 10.1073/pnas.1315022110
20. Tanner, K. (2012). Regulation of the basement membrane by epithelia generated forces. Physical Biology, 9(6), 065003. doi: 10.1088/1478-3975/9/6/065003
Before the NIH:
21. Tanner, K., Mori, H., Mroue, R., Bruni-Cardoso, A., & Bissell, M. (2012). Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proceedings Of The National Academy Of Sciences, 109(6), 1973-1978. doi: 10.1073/pnas.1119578109
22. Tanner, K., Boudreau, A., Bissell, M., & Kumar, S. (2010). Dissecting Regional Variations in Stress Fiber Mechanics in Living Cells with Laser Nanosurgery. Biophysical Journal, 99(9), 2775-2783. doi: 10.1016/j.bpj.2010.08.071
23. Ulrich, T., Jain, A., Tanner, K., MacKay, J., & Kumar, S. (2010). Probing cellular mechanobiology in three-dimensional culture with collagen agarose matrices. Biomaterials, 31(7), 1875-1884. doi: 10.1016/j.biomaterials.2009.10.047
24. Tanner, K., Ferris, D., Lanzano, L., Mandefro, B., Mantulin, W., & Gardiner, D. et al. (2009). Coherent Movement of Cell Layers during Wound Healing by Image Correlation Spectroscopy. Biophysical Journal, 97(7), 2098-2106. doi: 10.1016/j.bpj.2009.06.052
25. Tanner, K., Beitel, E., D’Amico, E., Mantulin, W., & Gratton, E. (2006). Effects of vasodilation on intrinsic optical signals in the mammalian brain: a phantom study. Journal Of Biomedical Optics, 11(6), 064020. doi: 10.1117/1.2398920
26. Tanner, K., D’Amico, E., Kaczmarowski, A., Kukreti, S., Malpeli, J., Mantulin, W., & Gratton, E. (2005). Spectrally resolved neurophotonics: a case report of hemodynamics and vascular components in the mammalian brain. Journal Of Biomedical Optics, 10(6), 064009. doi: 10.1117/1.2137291
Non-peer reviewed preprints:
1. Foss, A., Zanoni, M., So, W. Y., Jenkins, L., Tosatto, L., Bartolini, D., . . . Tanner, K*. (2020). Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway. bioRxiv 207233, doi:10.1101/2020.07.16.207233
2. Kong, M., Updegrove, T., B., Constantino, M., A., Gallardo, D., L., Wu,I., Fitzgerald, D., J.*, Tanner, K.*, Ramamurthi, K.* (2020). Cell-specific cargo delivery using synthetic bacterial spores. bioRxiv 94760, doi.org/10.1101/2020.02.13.94760
3. Paul, C., Hruska, A., Staunton J.R., Burr, H., A., Jiang, N., Kim, J., Tanner, K. (2017). Decoupling cellular response to topography and stiffness in three dimensions. bioRxiv 232066; doi: https://doi.org/10.1101/232066
4. Paul, C., Bishop, K., Devine, A., Wulftange, W., Paine, E., Staunton J.R., Shema, S., Bliskovsky, V., Jenkins, L., Morgan, N., Sood, R., Tanner, K. (2017). Tissue architectural cues drive the emergence of non-random trafficking of human tumor cells in the larval zebrafish. bioRxiv 233361; doi: https://doi.org/10.1101/233361
5. Paul, C., Devine, A., Bishop, K., Xu, Q., Daly, K.M., Lewis, C., Green, D.S., Staunton J.R., Liu, Z., Sood, R., Tanner, K. (2017). Human macrophages survive and adopt activated genotypes in living zebrafish. bioRxiv 181685; doi: https://doi.org/10.1101/181685
Selected for preLight, https://prelights.biologists.com/highlights/human-macrophages-survive-adopt-activated-genotypes-living-zebrafish/
